PredictaBall: NFL Week 1 Picks
Sept 4–7, 2025 – GMT
Mobile-first, single-column layout with NFL-specific fields and penalty forecasts.
#1
NFL – Week 1
Kickoff: Thu
Venue: Lincoln Financial Field
Dallas Cowboys
Philadelphia Eagles
Prediction
Cowboys 23 – 27 Eagles
Confidence: High (72%)
Penalty Risk: Medium
Betting
ResultEagles (8/11)
SpreadEagles -3.5 (10/11)
Total PointsOver 47.5 (10/11)
Winning MarginEagles by 1–6 (9/4)
Discipline
Total Flags Predicted12
Flag SplitCowboys 6, Eagles 6
Roughing/DP FlagYes (7/2)
#2
NFL – Week 1
Kickoff: Fri
Venue: TBA (International)
Los Angeles Chargers
Kansas City Chiefs
Prediction
Chargers 24 – 30 Chiefs
Confidence: High (68%)
Penalty Risk: Medium
Betting
ResultChiefs (4/7)
SpreadChiefs -6.5 (10/11)
Total PointsOver 50.5 (10/11)
Winning MarginChiefs by 7–12 (11/4)
Discipline
Total Flags Predicted11
Flag SplitChargers 5, Chiefs 6
Offensive Holding (10+ yds)Likely (2/1)
#3
NFL – Week 1
Kickoff: Sun
Venue: Cleveland Browns Stadium
Cincinnati Bengals
Cleveland Browns
Prediction
Bengals 20 – 23 Browns
Confidence: Medium (56%)
Penalty Risk: Low
Betting
ResultBrowns (21/20)
SpreadBrowns -2.5 (10/11)
Total PointsUnder 44.5 (10/11)
Winning MarginBrowns by 1–6 (2/1)
Discipline
Total Flags Predicted9
Flag SplitBengals 4, Browns 5
Defensive PIPossible (11/4)
#4
NFL – Week 1
Kickoff: Sun
Venue: Lucas Oil Stadium
Miami Dolphins
Indianapolis Colts
Prediction
Dolphins 27 – 23 Colts
Confidence: Medium (63%)
Penalty Risk: Low
Betting
ResultDolphins (10/11)
SpreadDolphins -2.5 (10/11)
Total PointsOver 48.5 (10/11)
Winning MarginDolphins by 1–6 (21/10)
Discipline
Total Flags Predicted10
Flag SplitDolphins 5, Colts 5
False Start (3+)Likely (6/4)
#5
NFL – Week 1
Kickoff: Sun
Venue: Lumen Field
San Francisco 49ers
Seattle Seahawks
Prediction
49ers 26 – 20 Seahawks
Confidence: High (66%)
Penalty Risk: Medium
Betting
Result49ers (8/13)
Spread49ers -4.5 (10/11)
Total PointsUnder 45.5 (10/11)
Winning Margin49ers by 7–12 (13/5)
Discipline
Total Flags Predicted11
Flag Split49ers 5, Seahawks 6
Unsportsmanlike (1+)Possible (5/2)
#6
NFL – Week 1
Kickoff: Sun
Venue: Highmark Stadium
Baltimore Ravens
Buffalo Bills
Prediction
Ravens 24 – 27 Bills
Confidence: Medium (64%)
Penalty Risk: Medium
Betting
ResultBills (5/6)
SpreadBills -2.5 (10/11)
Total PointsOver 49.5 (10/11)
Winning MarginBills by 1–6 (21/10)
Discipline
Total Flags Predicted12
Flag SplitRavens 5, Bills 7
Roughing the PasserPossible (9/4)
PredictaBall is a sister company of Bet Smart & Win; visit www.betsmart.win for all of our sports blogs.
Disclaimer: These are model-driven predictions and illustrative odds in fractional format. Always verify market lines before placing a bet and gamble responsibly.
Disclaimer: These are model-driven predictions and illustrative odds in fractional format. Always verify market lines before placing a bet and gamble responsibly.
davereddy04